You can resolve this issue by deleting the registry key and allowing Backup Exec to use its default I/O buffer size.
Complete the following steps to delete the registry key.
Warning: Incorrect use of the Windows registry editor may prevent the operating system from functioning properly. Great care should be taken when making changes to a Windows registry.
1. In Windows, click Start and then click Run.
2. Type Regedit.
3. Click OK.
The Registry Editor opens.
4. Navigate to the following path:
HKEY_LOCAL_MACHINE\SOFTWARE\Symantec\Backup Exec For Windows\Backup Exec\Engine\NTFS\
5. Select the following registry key:
FsIOBufferSize
6. Right-click the registry key and then click Delete.
7. Click Yes to confirm that you want to delete the registry key.
8. Close the Registry Editor.
NOTE: If this registry key does not exist this then the issue is not related to FsIOBufferSize key.